BenzenesulfonaMide, 2-[[5-broMo-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl-
2-[[5-Bromo-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide
CAS: 761436-81-1
Molecular Formula: C23H28BrN7O3S
BenzenesulfonaMide, 2-[[5-broMo-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl- - Names and Identifiers
BenzenesulfonaMide, 2-[[5-broMo-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl- - Physico-chemical Properties
| Molecular Formula | C23H28BrN7O3S |
| Molar Mass | 562.48 |
| Density | 1.472±0.06 g/cm3(Predicted) |
| Boling Point | 724.7±70.0 °C(Predicted) |
| Solubility | DMSO : 50 mg/mL mother liquor preservation: sub-package and freeze storage to avoid repeated freezing and thawing;-20 ℃,1 month;-80 ℃,6 months (after dilution, the solution temperature is low and storage may precipitate, try to use it now) Cell experiment: Dissolve with DMSO first: dilute with culture medium then, and the dilution process is recommended to be carried out in stages to avoid too fast concentration change leading to compound precipitation. If the compound is precipitated during the dilution process, it can be redissolved by ultrasound. During dilution, ensure that the final concentration of DMSO in the working fluid should be below 0.1% as far as possible, and the maximum should not exceed 0.5%, and set up a DMSO control group with corresponding concentration. Animal experiment: Dissolve with DMSO first: dilute with water or normal saline, etc. The dilution process is recommended to be carried out in sections to avoid excessive concentration changes leading to compound p |
| pKa | 11.27±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | ALK inhibitor 1 (compound 17) is a potent, pyrimidine-based ALK inhibitor. ALK inhibitor 1 is a potent testicular-specific serine/threonine kinase 2 (TSSK2; IC50 = 31 nM) and focal adhesion kinase (FAK; IC50 = 2 nM) inhibitor. |
| In vitro study | ALK inhibitor 1 (compound 17) inhibits IGF-1R with an IC 50 of 90 nM. |
BenzenesulfonaMide, 2-[[5-broMo-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl- - Reference
| Reference Show more | 1. Jon E Hawkinson, et al. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem. 2017 Nov 22;12(22):1857-1865. |
BenzenesulfonaMide, 2-[[5-broMo-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-4-pyriMidinyl]aMino]-N-Methyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.778 ml | 8.889 ml | 17.778 ml |
| 5 mM | 0.356 ml | 1.778 ml | 3.556 ml |
| 10 mM | 0.178 ml | 0.889 ml | 1.778 ml |
| 5 mM | 0.036 ml | 0.178 ml | 0.356 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 2-[[5-Bromo-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzenesulfonamide Visit Supplier Webpage Request for quotationCAS: 761436-81-1
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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